Menomellow
Search
✓ Reviewed by an OB-GYN✓ Prices verified monthly✓ Method published
GLP-1 / Compounded

Best Compounded GLP-1 Pharmacy: 20 Providers Compared (2026)

All twenty sell compounded semaglutide or tirzepatide, the two GLP-1 weight-loss medicines behind Wegovy and Zepbound. Their prices differ far more than the medicine does.

Jill Garnier, MD, FACOG, MSCPMedically reviewed by Jill Garnier, MD
✓ PRICES CHECKED · SEP 28, 202621 MIN READ
The short answer

Yes, compounded GLP-1 is still legal in 2026 when a licensed pharmacy makes it for one patient, on a prescription. Our pick is JoinSkinny, for one low semaglutide price at every dose with no prepay. If you can prepay six months, Nu Image Medical costs the least, about $90 a month for either medicine.

On this page
  1. What you'll actually pay
  2. Compounded GLP-1 prices compared: 20 providers for semaglutide and tirzepatide
  3. What does "compounded GLP-1" actually mean?
  4. Is compounded GLP-1 legal in 2026, or has it been banned?
  5. Is compounded GLP-1 safe?
  6. Where to find a reliable compounded GLP-1 pharmacy
  7. Compounded semaglutide vs. compounded tirzepatide: which is right for you
  8. How compounded GLP-1 pricing actually works
  9. Red flags before you enroll with any compounding pharmacy
  10. Compounded GLP-1 and perimenopause: does the hormonal context change anything
  11. Frequently asked questions

What you'll actually pay

We may earn a commission if you sign up through a link. It never affects the ranking. How we review

Sema is semaglutide, the medicine in Ozempic and Wegovy. Tirz is tirzepatide, the medicine in Mounjaro and Zepbound. Tirz acts on two appetite hormones instead of one. It often brings more weight loss, and it costs more.

Our pickBest for a flat price, no prepayJoinSkinny4.798 reviews on TrustpilotSema about $150 per 28 daysTirz priced after intake*
  • Visit and shipping included
  • Same price at every dose
  • Billed every 28 days, 13 times a year
  • 6-month results warranty, strict terms
See JoinSkinny's prices
Best for the lowest price, 6-month prepayNu Image Medical4.4998 reviews on TrustpilotSema about $90–$300Tirz about $90–$300*
  • Low price needs a 6-month prepay
  • About $200 on a 3-month plan
  • Same price at every dose
  • All sales final, auto-renew complaints
See Nu Image Medical's prices
Best for paying a year upfrontBetterMe Rx3.6498 reviews on TrustpilotSema about $100–$200Tirz about $160–$250*
  • Low price needs a year paid upfront
  • Same price at every dose
  • Visits and shipping included
  • No refunds, Trustpilot 3.6
See BetterMe Rx's prices
Arbor4.551 reviews on TrustpilotSema about $100–$150Tirz about $150–$250*
  • Low price needs a 12-month prepay
  • Same price at every dose
  • Visits, shipping and a dietitian included
  • No refunds once prescribed
See Arbor's prices
Best for Both medicines, pill or shotCurex4.3100 reviews on TrustpilotSema about $150–$300Tirz about $200–$400/mo*
  • Low prices need a year paid upfront
  • No membership
  • Visit, medicine and shipping included
  • Pill or shot
See Curex's prices
Show 15 more options
Best for tirzepatide plus hormone therapyGala4.64,223 reviews on TrustpilotTirz about $180–$200*
  • Prepaid, no refunds
  • Every dose included
  • Pharmacy not named, BBB C-
  • Hormone therapy on the same account
See Gala's prices
Oak4.454 reviews on TrustpilotSema about $120Tirz about $185*
  • 12-month plan
  • No card until a provider reviews you
  • Pharmacy not named
  • Trustpilot 4.4 on 54 reviews
See Oak's prices
TrimRx3.75,753 reviews on TrustpilotSema from about $180Tirz from about $260*
  • Low price needs a prepaid plan
  • Same price at every dose
  • Visits and shipping included
  • Trustpilot 3.7, billing complaints
See TrimRx's prices
Joi4.61,423 reviews on TrustpilotSema about $180Tirz about $250*
  • Billed every 3 months, no refunds
  • Lower first month
  • Coaching included
  • Hormone therapy on the same account
See Joi's prices
ReadyRx4.71,057 reviews on TrustpilotSema about $200–$250Tirz about $275–$315*
  • Low price needs a 3-month prepay
  • Same price at every dose
  • Written weight-loss guarantee
  • Not offered in some states
See ReadyRx's prices
Pallas HealthSema about $200Tirz about $300*
  • Billed every 4 weeks
  • First month from about $140
  • Same price at every dose
  • Charged only after a prescription
See Pallas Health's prices
MEDGmSema about $170–$300Tirz about $270–$400*
  • Low price needs a year upfront
  • Labs included
  • Same price at every dose
  • Tablet option
See MEDGm's prices
LevelsRxSema from about $250Tirz from about $350*
  • Unlimited video visits and coaching
  • Same price at every dose
  • Full price list only at intake
  • Very few reviews
See LevelsRx's prices
Direct Meds4.615,809 reviews on TrustpilotSema about $295Tirz about $400*
  • Shot or drops under the tongue
  • 6-month prepay about halves the price
  • Trustpilot 4.6, but 278 BBB complaints
See Direct Meds's prices
Best for the lowest month-to-month priceEden4.54,936 reviews on TrustpilotSema about $100Tirz about $130*
  • All in, no membership
  • Same price at every dose
  • No prepay
See Eden's prices
Mochi Health4.519,534 reviews on TrustpilotSema about $140–$270Tirz about $170–$280*
  • Price rises with the dose
  • $79 monthly membership included in these totals
  • Obesity-medicine doctors
See Mochi Health's prices
Fridays4.14,754 reviews on TrustpilotSema about $150–$280Tirz about $240–$390*
  • Low price needs a year paid upfront
  • Dietitian and group coaching included
  • No membership fee
  • BBB F, refund complaints
See Fridays's prices
Peak WellnessSema about $165–$250Tirz about $230–$350*
  • Low price needs a 6-month prepay
  • Same price at every dose
  • No membership fee
See Peak Wellness's prices
Henry Meds4.412,532 reviews on TrustpilotSema about $250–$295Tirz about $350*
  • Sema pill or shot, tirz pill only
  • Visits, supplies and shipping included
  • No membership, cancel anytime
  • Ask your higher-dose price
See Henry Meds's prices
Willow3.9360 reviews on TrustpilotSema about $300Tirz about $400–$550*
  • Tirz price rises with dose
  • No membership fee
  • LegitScript certified
  • Only 36 states
See Willow's prices
✓ Prices checked · Sep 28, 2026 · re-checked monthly

Compounded GLP-1 prices compared: 20 providers for semaglutide and tirzepatide

Each price includes the visit, the medicine and shipping. Start with the line that sounds like you.

  • Low price with no prepay or membership: JoinSkinny, for semaglutide.
  • Lowest price overall: Nu Image Medical, if you can prepay six months. BetterMe Rx, Arbor and Oak come next on a prepaid year.
  • Lowest without a prepay: Eden, about $100 a month for semaglutide or $130 for tirzepatide, at every dose.
  • Hormone therapy on the same account: Gala for tirzepatide, or Joi for both medicines.
  • The most support: Fridays, with a dietitian and group coaching.
  • Video visits with a clinician: LevelsRx.
  • No needle: Henry Meds sells pills, and Direct Meds sells drops under the tongue.

JoinSkinny: about $150 for semaglutide, the same at every dose

JoinSkinny charges the same semaglutide price at every dose. Your bill does not climb as the dose goes up. Doctors from the OpenLoop network prescribe, and its terms name the partner pharmacies.

It also offers a weight-loss warranty, which is rare. You can get your fees back if you miss your goal weight after six months. The rules are strict, so read them before you count on it.

Two things to know. Billing comes every 28 days, so you pay 13 times a year, about $1,940 in total. Tirzepatide is priced only after the intake, so we cannot call it a low-price option yet. It is also a young brand with few reviews.

Our pick: one flat semaglutide price, no prepay
JoinSkinny: about $150 every 28 days at every dose · Visit and shipping included · Read the warranty terms before you enroll
See JoinSkinny pricing

Nu Image Medical: the lowest price if you prepay six months

Nu Image Medical, a Tampa clinic online since 2008, has the lowest price on this page for both medicines. The catch is that it needs six months paid at once. The price stays the same at every dose, and shipping is free.

  • Semaglutide: $89 a month on the 6-month plan, billed every six months · $199 a month on 3 months · $299 month to month
  • Tirzepatide: the same prices as semaglutide, at every dose
  • Good to know: its semaglutide is mixed with vitamin B12

Its terms name the prescribing medical group and four compounding pharmacies. All sales are final, and plans renew on their own until you cancel, at least 48 hours before the renewal date. Most complaints filed with the Better Business Bureau are about those renewals and refunds. Trustpilot rates it 4.4 out of 5, on about 1,000 reviews.

BetterMe Rx: among the lowest prices if you pay a year upfront

BetterMe Rx has among the lowest rates on this page for both medicines. The catch is that they apply only to its 12-month plan, paid in one go. The price stays the same at every dose, and visits and shipping are included.

  • Semaglutide: about $100 a month on the year plan, one payment of about $1,190 · About $200 month to month
  • Tirzepatide: about $160 a month on the year plan, one payment of about $1,910 · About $250 month to month

It is open about who does the work. Its FAQ names the doctor networks, TelegraMD and Dr. TelX, and seven U.S. pharmacies with their addresses.

The weak spots are refunds and reviews. Nothing is refunded once an order is processed, unused prepaid months included. Trustpilot rates it 3.6 out of 5, with complaints about leaking vials.

It also sells tirzepatide tablets. No study shows tirzepatide works when swallowed, so choose the weekly shot.

Arbor: among the lowest prices if you pay a year upfront

Arbor, formerly Harbor, matches BetterMe Rx on semaglutide and costs a little less for tirzepatide, on a prepaid year. Its partner medical group, MD Integrations, handles the doctor visits. There is no membership fee.

  • Semaglutide: $99/mo on a 12-month plan, charged once as $1,188 · $149 month to month
  • Tirzepatide: $149/mo on a 12-month plan, charged once as $1,788 · $249 month to month
  • Included: visits, check-ins, shipping and a dietitian, the same price at every dose

It does not name its pharmacies. Read the refund rules before you prepay. Once a prescription is written, nothing is refunded, including months not yet shipped. Its 12-month money-back guarantee excludes anyone who took a weight-loss drug in the year before. Trustpilot rates it 4.5 out of 5, on only 51 reviews under its old Harbor name.

Curex: both medicines, as a pill or a shot, no membership

Curex has no membership fee. The visit, the medicine, shipping and unlimited follow-ups all sit in one price. You can choose a pill or a shot for either medicine. Its low prices, about $150 a month for semaglutide and about $200 for tirzepatide, need a year paid upfront.

Month to month, semaglutide costs about $200 as a pill and about $250 as a shot, at the starting dose. Tirzepatide costs about $250 as a pill and about $300 as a shot. Each costs $50 to $100 more at higher doses.

  • Pros: a low start for both medicines, no membership, pill or shot, unlimited follow-ups.
  • Cons: the price at higher doses is not published.
Curex: semaglutide from about $150 a month, tirzepatide from about $200, on a prepaid year · No membership
See Curex pricing

Gala: tirzepatide and hormone therapy on one account

Gala is aimed at women in midlife. Its only priced compounded medicine is tirzepatide. Estradiol, progesterone and non-hormonal hot-flash options sit on the same account, from about $70 a month. Its clinicians prescribe in all 50 states.

  • Tirzepatide: about $180 a month on the yearly plan · About $200 a month on the 3-month plan
  • Included: the assessment, dose changes, messaging and shipping, with the same price at every dose

Both plans are paid ahead, and nothing is refunded if you cancel. Gala does not name its pharmacy, so you cannot check its inspection record. The Better Business Bureau, a consumer complaints service, grades it C-, with repeated billing complaints.

The 3-month plan is the safer way in. For the full picture, see our Gala review.

Tirzepatide with hormone therapy: Gala
About $180 a month on the yearly plan · About $200 on the 3-month plan · Every dose included · Prepaid, no refunds, so start with 3 months
See Gala pricing

Oak: among the lowest 12-month rates, with less transparency

Oak is a small cash-pay telehealth brand run by Oak Longevity Holdings Corp. It sells compounded semaglutide and tirzepatide. No card is taken until a provider reviews your intake.

  • Semaglutide: about $120 a month on a 12-month plan
  • Tirzepatide: about $185 a month on a 12-month plan
  • Shorter plans: priced only at checkout

The trade-off is transparency. Oak never names its medical group or its pharmacy. Nothing is refunded once an order reaches the pharmacy. Trustpilot rates it 4.4 out of 5, on only 54 reviews.

TrimRx: from about $180, the same at every dose

TrimRx promises a price that never climbs with the dose, and it keeps that promise. Whatever plan rate you start on holds through every dose. Visits, supplies and shipping are included.

  • Semaglutide: from about $180 a month on a prepaid plan · Month to month, about $200 the first month, then about $300
  • Tirzepatide: from about $260 a month on a prepaid plan · Month to month, about $350 the first month, then about $400

TrimRx does not name its pharmacy on its own site. Unused prepaid months are not refunded once the medicine ships.

Read the billing terms twice. Trustpilot rates it 3.7 out of 5, and about 3 in 10 reviews are one-star, mostly about auto-renewals and refunds. The Better Business Bureau gives it an F.

Joi: semaglutide or tirzepatide from a hormone clinic

Joi is the women's side of Joi + Blokes, a hormone clinic that added compounded GLP-1s. It suits you if you want one clinician looking at weight and perimenopause together. Estradiol, progesterone and testosterone sit on the same account.

  • Semaglutide: about $180 a month · First month about $100
  • Tirzepatide: about $250 a month · First month about $150
  • Included: unlimited health coaching and clinician messaging

The catch is the contract. Every plan is billed every three months, with a three-month minimum. The terms say no product is refunded. Prices differ in New York and New Jersey.

ReadyRx: about $200 for semaglutide on a 3-month plan

ReadyRx keeps it simple, with one price at every dose and no membership fee. Cold shipping is free. New patients who follow their prescribed doses get a written weight-loss guarantee.

  • Semaglutide: about $200 a month on the 3-month plan · About $250 month to month
  • Tirzepatide: about $275 a month on the 3-month plan · About $315 month to month
  • First month: $20 off

Trustpilot rates it 4.7 out of 5, on about 1,050 reviews.

ReadyRx does not name its pharmacy before you enroll, and care is by text only. It is not offered in about seven states for semaglutide and nine for tirzepatide. California and North Carolina are among the tirzepatide gaps. You only find out during intake.

Pallas Health: charged only after a prescription

Pallas Health is a new platform, launched in mid-2026. It names its medical group, Lion MD, and six partner pharmacies. You pay nothing until a clinician actually prescribes.

  • Semaglutide: about $200 every 4 weeks · First month about $140
  • Tirzepatide: about $300 every 4 weeks · First month about $180
  • Prepay: paying 48 weeks upfront lowers them to about $140 and $240 every 4 weeks

Billing every 4 weeks means 13 charges a year, not 12. The catch is the track record: we found no independent reviews yet.

MEDGm: labs included, cheapest if you prepay a year

MEDGm is a very new online clinic run by MEDGm, LLC, a Delaware company. Clinicians from the OpenLoop network prescribe. Its terms name four partner pharmacies.

  • Semaglutide: about $300 month to month · About $170 a month on a 12-month plan paid upfront
  • Tirzepatide: about $400 month to month · About $270 a month on a 12-month plan paid upfront
  • First month: $120 off with the code WELCOME120OFF
  • Included: visits, lab work and shipping, with the same price at every dose

It also offers a daily semaglutide tablet. You pay at intake, before a clinician reviews you. We found no customer reviews yet.

LevelsRx: from about $250, with video visits included

LevelsRx puts a clinician on camera instead of behind a questionnaire. Unlimited video visits, one-on-one nutrition coaching and shipping are included. Its terms name its partner pharmacies.

  • Semaglutide shot: from about $250 a month
  • Semaglutide liquid by mouth, daily: from about $270 a month
  • Tirzepatide: from about $350 a month

The site says the price stays the same at every dose. At these rates it sits near the top of this page, so you are paying for the video care and coaching. The full plan prices appear only once you start the intake. It is also a new brand, with very few public reviews.

Direct Meds: shots or drops, cheaper on a 6-month prepay

Direct Meds sells compounded semaglutide and tirzepatide as shots or as drops under the tongue. The visit, supplies and shipping are in one price, the same at every dose. It serves every state except Mississippi and Louisiana.

  • Semaglutide shot: about $295 a month · About $145 a month on a 6-month prepay
  • Tirzepatide shot: about $400 a month · About $200 a month on a 6-month prepay
  • First month: about $145 for semaglutide or $200 for tirzepatide with its current promo

Trustpilot rates it 4.6 out of 5, on thousands of reviews. The Better Business Bureau lists 278 complaints in three years, mostly about billing and cancellations. Direct Meds names neither its pharmacy nor its medical group.

Mochi Health: priced by dose, plus a membership

Mochi bills in two parts. Since August 2026, the medicine is priced by dose. A $79 monthly membership comes on top and covers doctors certified in obesity medicine.

  • Semaglutide, all-in: about $140 to $270 a month, depending on the dose
  • Tirzepatide, all-in: about $170 to $280 a month, depending on the dose
  • First month: about $100 for semaglutide or $130 for tirzepatide, thanks to a cheaper first membership

Its starting-dose price is low, though Eden's flat price is lower without a prepay. Your bill rises as your dose goes up, so price the dose you expect to stay on. For the full audit, see our Mochi Health review.

  • Pros: a low price at the starting dose, and doctors certified in obesity medicine.
  • Cons: the advertised medicine price leaves out the $79 membership.
Mochi Health: semaglutide about $140–$270 a month · Tirzepatide about $170–$280 · Membership included in these totals
See Mochi Health

Fridays: a dietitian and coaching in the price

Fridays sells a program, not just a prescription. Dietitian visits, weekly group coaching and messaging are included at every price. There is no separate membership fee.

  • Semaglutide: about $150 a month on the yearly plan · About $280 month to month
  • Tirzepatide: about $240 a month on the yearly plan · About $390 month to month
  • Fall sale: codes on its pricing page lower the yearly plan to about $115 for semaglutide and $200 for tirzepatide, with no end date shown
  • Pros: real support built in, and a low yearly rate.
  • Cons: the low rate needs a year paid upfront. The Better Business Bureau rates Fridays F, with complaints about refunds on those prepayments.

For more, see our Fridays review.

Eden: the lowest price without a prepay

Eden charges one price at every dose, so moving up in dose does not raise your bill. There is no membership and no prepay.

  • Semaglutide: about $100 a month, all in
  • Tirzepatide: about $130 a month, all in

Two cautions: a June 2026 FDA warning letter over its marketing, and a BBB rating of F. For more, see our Eden review.

Peak Wellness: cheaper the longer you commit

Peak Wellness keeps one price at every dose, with no membership fee. What changes the price is how many months you pay ahead.

  • Semaglutide: about $250 month to month · About $165 a month on a 6-month plan · First month about $180
  • Tirzepatide: about $350 month to month · About $230 a month on a 6-month plan · First month about $280

The low prices in its ads are the prepaid rates. Check which rate your plan locks in before you pay.

Henry Meds: a pill or a shot for both medicines

Henry Meds offers a pill for both medicines, next to the usual shot. That matters if needles are what keep you from starting.

  • Semaglutide: about $250 a month as a pill · About $295 as a shot
  • Tirzepatide: about $350 a month as a pill · About $450 as a shot
  • Prepay: the semaglutide shot drops to about $245 a month on 6 months, or $195 on 12 months

Visits, supplies and shipping are included, with no membership fee. You can cancel month to month. Henry does not promise one price at every dose, so ask for the price at your long-term dose. For the full picture, see our Henry Meds review.

  • Pros: pill or shot for both medicines, everything bundled, cancel anytime.
  • Cons: the highest starting price for a tirzepatide shot on this page, and no coaching like Fridays offers.
Need an option without needles?
Henry Meds: compounded semaglutide as a pill or a shot, or tirzepatide as a pill, all-in from about $250 a month.
See Henry Meds

Willow: one all-in bill, in 36 states

Willow charges one all-in monthly price, with no membership fee. Both medicines come as a shot or as a tablet that dissolves in your mouth.

  • Semaglutide: about $300 a month · Same at every dose up to 3.5 mg
  • Tirzepatide: about $400 a month at the starting doses · About $500 to $550 at the higher doses

Willow holds LegitScript certification. LegitScript is an independent check that an online pharmacy or clinic follows the law. The limit is geography: Willow serves 36 states, so confirm yours first. See our Willow review.

  • Pros: same price at every dose, LegitScript certified, a tablet option.
  • Cons: among the higher prices here, 36 states only, and no live video visits.

What does "compounded GLP-1" actually mean?

Compounded GLP-1 is semaglutide or tirzepatide made by a licensed pharmacy for one patient. It is not a finished, FDA-approved product. The active ingredient is the same one found in Ozempic, Wegovy, Mounjaro or Zepbound.

The real difference is the review. The FDA checks brand-name drugs for strength, purity, sterility and consistency before they reach a pharmacy. A compounded version skips that check. A state-licensed pharmacy still makes it under pharmacy law, and a prescriber still signs off.

That is why the rules on when compounding is allowed matter as much as the price.

It has not been banned. It is just no longer the free-for-all it was in 2023.

Back then, both medicines were on the FDA's shortage list. A shortage lets pharmacies make copies at scale for anyone. Tirzepatide came off that list at the end of 2024. The FDA declared the semaglutide shortage over on February 21, 2025.

What survived is narrower. A 503A pharmacy compounds only against a prescription for one named patient. It can still make either medicine when a prescriber documents a medical reason the brand-name version will not work. An allergy to an inactive ingredient is one example. A dose strength the brand does not sell is another.

The FDA also said it generally will not act against a pharmacy that fills four or fewer such prescriptions a month. A lower price is not a medical reason on its own. The FDA's compounder policy statement has the details.

A 503B facility is different. It is an outsourcing plant that makes large batches without a named patient.

  • Tirzepatide: shortage-era compounding ended on February 18, 2025 for 503A pharmacies, and on March 19, 2025 for 503B facilities.
  • Semaglutide: shortage-era compounding ended on April 22, 2025 for 503A pharmacies, and on May 22, 2025 for 503B facilities.
  • Still legal: 503A compounding for one named patient with a documented medical need. This is the route the providers on this page rely on.
  • Not a reason on its own: wanting a lower price than the brand-name drug.
  • Pending: on April 30, 2026, the FDA proposed not to add semaglutide, tirzepatide and liraglutide to the list 503B facilities may use. Comments closed on July 30, 2026. No final rule had been issued as of September 28, 2026, and the proposal does not touch the 503A route.

Is compounded GLP-1 safe?

It is the same active medicine with different oversight. The FDA does not check a compounded version's strength, sterility or consistency the way it checks Wegovy or Zepbound. So the quality of your pharmacy matters more than it would with a brand-name drug.

Some compounded versions also add extras like vitamin B12 or L-carnitine. These are not in the FDA-approved brands. The mixes have not been tested the way the brand-name drugs were.

This is not hypothetical. In March 2025, Washington state's pharmacy commission issued a stop-service order against Aequita Pharmacy, a compounder of GLP-1 medicines. It cited untrained staff doing sterile compounding and poor supervision.

So ask about the pharmacy behind your prescription, not just the brand on the box. A clinician who reviews your health history and documents a real reason for compounding is doing the part that keeps you safest.

  • Ask which pharmacy fills your prescription. Check that its state board licenses it, or that PCAB, an independent quality program for compounders, accredits it.
  • Ask whether the formula contains anything beyond the active medicine, and why.
  • A good program names its pharmacy without hesitation. One that will not is a warning sign.

If side effects worry you more than legitimacy, know that they do not change because a medicine is compounded. See the full rundown in GLP-1 side effects.

Where to find a reliable compounded GLP-1 pharmacy

The best compounded GLP-1 pharmacy for you is not always the cheapest one. Look for three things. The program names its pharmacy partner. It publishes its price at every dose, not just a "starting at" number. And a prescriber will talk with you about why compounding fits your case.

Among the providers above, JoinSkinny, BetterMe Rx, Nu Image Medical, LevelsRx, Pallas Health and MEDGm name their pharmacies in writing. Gala, Oak, Arbor, Direct Meds, ReadyRx and TrimRx do not name theirs on their own sites.

Compounded semaglutide vs. compounded tirzepatide: which is right for you

Tirzepatide costs more than semaglutide at every provider here. The gap is usually $50 to $150 a month.

The gap follows how they work. Semaglutide acts on one gut hormone signal, called GLP-1. Tirzepatide acts on two, GLP-1 and GIP. That double action has produced more weight loss on average in trials.

It is still a trade-off, not a clear winner. Some women feel side effects differently on tirzepatide. Semaglutide has the longer real-world record, simply because it reached the market first.

For the full legal, safety and provider detail on each medicine, see compounded semaglutide and compounded tirzepatide.

How compounded GLP-1 pricing actually works

The advertised price is rarely the whole story. Most providers here keep one price at every dose, so raising your dose step by step does not raise your bill.

JoinSkinny, BetterMe Rx, Arbor, Nu Image Medical, Eden, Peak Wellness, LevelsRx, TrimRx, Gala, ReadyRx, Pallas Health, MEDGm and Direct Meds all promise this.

A few do not. Mochi's medicine price rises with your dose, and its $79 membership comes on top. Henry Meds prices by format, pill or shot, and does not promise one price at every dose. Oak's terms let its price change with your dose. Curex charges more at higher doses. Willow keeps semaglutide at one price, but its tirzepatide price climbs with the dose.

Intro rates and ongoing rates are a second thing to watch. BetterMe Rx, Arbor, Nu Image Medical, Fridays, Peak Wellness, TrimRx, Gala, ReadyRx, MEDGm, Pallas Health and Direct Meds all cut the monthly price if you pay months ahead. The cut is often 20 to 50 percent. So the number in the ad and the number on your sixth bill can differ.

Over a full year, the spread is wide. Nu Image Medical's tirzepatide on two 6-month plans comes to about $1,070. Willow's tirzepatide starts at about $400 a month, so a year costs at least $4,790. That is a gap of about $3,700 or more for the same medicine.

For what drives GLP-1 prices in general, brand-name or compounded, with or without insurance, see GLP-1 cost and GLP-1 without insurance.

Red flags before you enroll with any compounding pharmacy

  • The provider will not name the pharmacy that fills your prescription.
  • There is no consult or intake review at all, just a checkout page and a shipment.
  • The price at higher doses is not published anywhere, even when you ask.
  • Billing every 28 days without saying so clearly. That means 13 charges a year, not 12.
  • A multi-month prepay with no written refund or cancellation policy.
  • A price far below everything else on this page, with no explanation.

Compounded GLP-1 and perimenopause: does the hormonal context change anything

Weight that shows up in your forties and fifties is not only about habits. Falling estrogen shifts more fat toward the belly. Your body also tends to respond less well to insulin in these years.

Both make weight harder to manage with diet alone. That does not change which pharmacy is cheapest. It does explain why a program with coaching and a dietitian, like Fridays, can be worth more to you than its bare price suggests.

If the hormone side matters to you, ask any provider a direct question. Do its clinicians know perimenopause, or is it the same weight-loss script for every age? Joi, Gala and Mochi Health also offer hormone therapy on the same account.

For the wider picture, including how GLP-1s compare with hormone therapy, see GLP-1 medications and menopause weight gain. For brand-name and compounded options together, see cheapest GLP-1 providers and best online GLP-1 providers.

Frequently asked questions

What is compounded GLP-1, exactly?+

It is semaglutide or tirzepatide made by a licensed pharmacy for one patient. It is not a finished, FDA-approved drug like Wegovy, Ozempic, Mounjaro or Zepbound. The active ingredient is the same. The difference is that the FDA has not checked the compounded version for strength, sterility and consistency.

Has compounded GLP-1 been banned?+

No. What changed in 2025 is the legal path. Once the FDA declared both shortages over, mass compounding ended. A 503A pharmacy can still make it for one named patient with a documented medical reason. An FDA proposal from April 2026 targets bulk 503B compounding only, not this 503A route.

Is compounded GLP-1 safe?+

It carries different risks than brand-name GLP-1s, because the FDA does not check a compounded version's sterility or consistency. That does not make it unsafe by default. It does make your pharmacy and prescriber important. In 2025, Washington state ordered a GLP-1 compounding pharmacy to stop service over sterile-compounding failures. Ask any provider which pharmacy fills your prescription and whether it is licensed or accredited.

What's the cheapest compounded GLP-1 pharmacy that offers both semaglutide and tirzepatide?+

If you can prepay six months, Nu Image Medical is cheapest for both, at about $90 a month for either medicine, and all its sales are final. On a prepaid year, Arbor comes to about $100 a month for semaglutide and about $150 for tirzepatide. BetterMe Rx matches it on semaglutide and costs about $160 for tirzepatide. Neither refunds a prepaid year once the order is under way. Without a prepay, Eden is lowest, at about $100 a month for semaglutide and about $130 for tirzepatide, at every dose. Mochi Health's price rises with the dose. JoinSkinny starts at about $150 for semaglutide. It keeps that price at every dose but bills every 28 days.

Should I choose compounded semaglutide or compounded tirzepatide?+

It depends on your budget and how your body responds. Tirzepatide costs more at every provider here, usually $50 to $150 a month more. It acts on two hormone signals, GLP-1 and GIP, instead of one. It has produced more weight loss on average in trials. Semaglutide has the longer real-world record. See compounded semaglutide and compounded tirzepatide for the full comparison.

What is the difference between 503A and 503B compounding?+

A 503A pharmacy compounds a medicine only after it gets a prescription for one named patient. The providers on this page rely on that route. A 503B outsourcing facility makes larger batches without a named patient, usually for hospitals and clinics. For semaglutide and tirzepatide, the 503B route is effectively closed, because neither drug is in shortage now.

Will compounded GLP-1 be banned entirely in the future?+

The rules could narrow further. But no current proposal would end the 503A route for one named patient. The FDA's April 2026 proposal covers only the 503B bulk list. Its comment period closed on July 30, 2026, and no final rule had been issued by September 28, 2026. If you plan to stay on a compounded program for long, check the legal status from time to time.

Does being in perimenopause change whether compounded GLP-1 is a good option?+

The medicine works the same way at any age or hormonal stage. What can matter more in perimenopause is the support around the prescription. Fat storage and insulin response often shift in this decade. That is why coaching and a dietitian, as Fridays offers, may be worth more to you than the bare price suggests. Ask any provider whether its clinicians have experience with perimenopause.

Related reading

Perimenopause changes month to month. So do the prices.

Get our new guides and verified price checks by email, about once a week. No spam, no selling your address.

Not sure HRT is your answer?
Two minutes, no email required. You get matched to the treatment path that fits your symptoms.
Start the quiz